German Researchers Develop Novel 3D Cell Culture Technique to Study Gliomas in Real Time
According to Dr. Savaskan, the new approach will allow new medications and therapies to be analyzed and enable side effects to be identified more quickly and efficiently than when using conventional cell culture techniques. “VOGIM is a complex technique that allows tumors to be studied in real time and under clinically realistic conditions,” he explained.
In the method tissue samples from rodent brains are infected with tumor cells expressing fluorescent reporter genes. The growth of tumor cells and blood vessels, cell death, and the influence of medications on these developments are observed in the experiment.
“Even though VOGIM still requires some animal testing, it is a great technique. It can be used to test the effectiveness of new medications and molecules against gliomas relatively quickly and in a way that is reproducible,” continued Dr. Savaskan. “We can also use it to study the side effects of almost any medication.”
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